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Why has there been so little progress on Alzheimer's disease?

Agents Aren't Coworkers, Embed Them in Your Software

DeepSeek-V4 on Day 0: From Fast Inference to Verified RL with SGLang and Miles

Her Life Savings Mysteriously Disappeared After a Systems Glitch

Colorado Adds Open-Source Exemption to Age-Verification Bill

Trump fires NSF's oversight board

USB Cheat Sheet (2022)

The AI Industry Is Discovering That the Public Hates It

Can you stop beans from making you gassy?

Nicholas Carlini – Black-hat LLMs [video]

The Stanford Freshmen Who Want to Rule the World

America's Geothermal Breakthrough

IPv7: Identity-Centric Network Protocol – IETF Draft and Rust Implementation

Show HN: Kloak, A secret manager that keeps K8s workload away from secrets

North American Millets Alliance

Mine, an IDE for Coalton and Common Lisp

Amateur armed with ChatGPT solves an Erdős problem

Hokusai and Tesselations

Simulacrum of Knowledge Work

Framework Laptop 13 Pro: Major Upgrades and Linux Front and Center

Iran caused more extensive damage to U.S. military bases than publicly known

Using coding assistance tools to revive projects you never were going to finish

Niri 26.04: Scrollable-tiling Wayland compositor

What's missing in the 'agentic' story: a well-defined user agent role

UK to permanently ban future generations from buying cigarettes

Jumping into cold water can stop your heart

GPT‑5.5 Bio Bug Bounty

A Collection of Chronic Medical Conditions Common in Autistic and ADHD Adults [pdf] (2023)

HEALPix

Lambda Calculus Benchmark for AI

Discret 11, the French TV encryption of the 80s

Only one side will be the true successor to MS-DOS – Windows 2.x

A web-based RDP client built with Go WebAssembly and grdp

Martin Galway's music source files from 1980's Commodore 64 games

Show HN: A Karpathy-style LLM wiki your agents maintain (Markdown and Git)